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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 11
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Original Articles

Microwave-Assisted Amidation of Arylacetic Acids by Reaction with 2-Aryl-ethylamines

, , , , &
Pages 1491-1498 | Received 14 Nov 2011, Published online: 06 Mar 2013
 

Abstract

Twenty-five amides were synthesized in almost quantitative yields by microwave-assisted condensation of arylacetic acids and 2-aryl-ethylamines under solventless conditions. The N-arylethyl-arylacetylamides are intermediates of the corresponding isoquinoline derivates.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

This project was supported by the Hungarian Scientific and Research Fund (OTKA K83118). This work is connected to the scientific program of the “Development of Quality-Oriented and Harmonized R+D+I Strategy and Functional Model at BME” project. This project is supported by the New Hungary Széchenyi Plan (Project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002).

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