Abstract
Trifluoromethylation of carbonyl compounds using (trifluoromethyl) trimethylsilane catalyzed by 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding α-trifluoromethyl alcohols in good to excellent yields under mild reaction conditions.
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GRAPHICAL ABSTRACT
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Notes
a 1 mol% of TBD was used.
b MTBD, 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene.
c TMG, tetramethyl guanidine.
a 10 mol% of TBD was used.