Abstract
A series of N-substituted phthalimides was synthesized by a thermal reaction between N,N′-disubstituted ureas and phthalic acid catalyzed by imidazole in solventless conditions. The products have been obtained in moderate to good yields (53–92%).
Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.
GRAPHICAL ABSTRACT
![](/cms/asset/6e0e2b93-f0ba-467b-8843-27e85a252d79/lsyc_a_651677_o_uf0001.gif)
Keywords:
ACKNOWLEDGMENTS
The authors are grateful to Pernambuco State Foundation of Science and Technology (FACEPE-PRONEM No. 1232.1.06/10) for financial support and DQF-UFPE for obtaining the spectral data.
Notes
a Chemical yield of pure product after recrystallization from ethanol.
b Experiment performed employing 2 eq. of urea and 1.5 eq. of imidazole.
a Experiment has been done at 25-mmol scale.