Abstract
The synthesis of a series of amino ethers was carried out in a two-step method involving phosphorylation of the corresponding amino alcohols and subsequent double displacement via an aziridinium intermediate. The new products were obtained in good yields with excellent regioselectivity.
GRAPHICAL ABSTRACT
![](/cms/asset/fb74b3ec-1227-43cf-8cce-dbb5d9a131a0/lsyc_a_653703_o_uf0001.gif)
ACKNOWLEDGMENT
We thank M. A. Sanhoury, member of the Royal Society of Chemistry (MRSC) of the Department of Chemistry, Faculty of Sciences of Tunis, for helpful discussions.
Notes
a 4b and c were 1:1 mixtures of two diastereomers (α + β) derived from the 1:1 mixture of 3b and c.
b Yields refer to chromatographically isolated pure compounds.
a 5b and c were 1:1 mixtures of two diastereomers (α + β) derived from the 1:1 mixture of 4b and c.
b Yields refer to chromatographically isolated pure compounds.