Abstract
A mixture of potassium hydroxide and potassium phosphate was found to be an active reagent mixture for the cleavage of 2-hydroxypropyl-protected acetylenes. The reaction was performed in toluene at reflux temperature and gave terminal acetylenes in good to excellent yields within very short periods of time. Numerous other functional groups are tolerated.
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GRAPHICAL ABSTRACT
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Notes
a Yields refer to isolated products characterized by spectroscopic data (1H and 13C NMR, MS, and IR analyses).