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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 22
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Original Articles

Concise Stereoselective Total Synthesis of (4R, 6R)-Lactone Moiety Analog of Mevinoline and Compactin

, , , &
Pages 2980-2984 | Received 18 Jul 2012, Published online: 08 Aug 2013
 

Abstract

A simple and highly efficient synthetic route has been developed for analogue of HMGCo A reductase inhibitor (1). The strategy utilizes S-Corey–Bakshi–Shibata (CBS) reduction, FeCl3-catalyzed C-H insertion of ethyl diazoacetate.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource: Full experimental and spectral details.]

GRAPHICAL ABSTRACT

ACKNOWLEDGMENT

The authors are thankful to the Council of Scientific and Industrial Reserch, New Delhi, India, for financial support.

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