Nitrogen-Containing Six-Membered Heterocycles: Solid-Phase Synthesis

Abstract

Solid-phase organic synthesis is a rapidly expanding area of synthetic chemistry that is being widely exploited in the search for new medicinally important compounds using combinatorial techniques. In recent decades, a large number of reports related to solid-phase synthesis of heterocycles have appeared because of the wide variety of their biological activity. In this review, we report the important role of solid-phase synthesis in the synthesis of nitrogen containing six-membered ring heterocycles.

GRAPHICAL ABSTRACT

Keywords:

• Heterocycles
• solid-phase synthesis
• solvent-free synthesis