Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 22
1,402
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

One-Pot Synthesis of 3,4-Dihydropyridin-2-one via Michael Addition of in situ–Generated Enaminones

, &
Pages 3010-3019 | Received 25 Oct 2012, Published online: 08 Aug 2013
 

Abstract

Herein we have reported a facile solvent-, catalyst-, and aldehyde-free, one-pot synthesis of 3,4-dihydropyridin-2-one from 1,3-diones using simple and mild reaction conditions. The substrate scope has been also extended to β-ketoesters.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource: Full experimental and spectral details.]

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

J. B. Senthil Kumar acknowledges the Department of Biotechnology (DBT), New Delhi, and the Council for Scientific and Industrial Research (CSIR), New Delhi, for providing financial support, and Neeta Kumari is thankful to Pratibha Mehta Luthra, Neuropharmaceutical Laboratory, B. R. Ambedkar Centre for Biomedical Research, University of Delhi, for providing supervision and laboratory facilities to carry out this work.

Notes

a Isolated yield.

b Starting materials were present.

c Polymerisation was observed.

a Isolated yield.

b Inseparable mixture.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.