Abstract
5-Ethyl-3-methyl-2′,4′:3′,5′-di-O-methylenedioxyriboflavinium perchlorate (1, DMRFlEt+ClO4 –), derived readily from commercially available vitamin B2 (riboflavin), exhibits high catalytic activity for the oxidation of organic sulfides with hydrogen peroxide. The reaction provides an efficient and selective method for the oxidative transformation of organic sulfides to the corresponding sulfoxides under mild conditions.
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GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Notes
a The reaction of sulfide (1 mmol) was carried out in MeOH (1 mL) in the presence of 1 (0.02 mmol) and a 30% aqueous solution of H2O2 (1.5 mmol) at ambient temperature.
b Isolated yield.
c 1 (0.01 mmol), 30% H2O2 aqueous solution (1.1 mmol).
d CH2Cl2 (1 mL) was used instead of MeOH.