Abstract
Short and efficient route for the synthesis of oxazinone- and thiazinone-containing bicyclic heteroaromatic aldehydes, which involves the key step of palladium-catalyzed reductive carbonylation, is described. Overall routes for the synthesis of these aldehydes are short, versatile, and scalable with good yields of the product.
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GRAPHICAL ABSTRACT
![](/cms/asset/73c02973-1e79-4fb7-8686-9c37c1bd775a/lsyc_a_781183_o_uf0001.gif)
ACKNOWLEDGMENTS
We deeply acknowledge the analytical support provided by Suresh Rudrapatna, Sandesh Jatheendranath, and Sreenivasaiah Menasinkai. We also thank Eknath Bellale for proofreading this article.
Notes
a Isolated yields after column purification.
b Mixture of compounds 2a and 6.
c Only debrominated product 6.