An Expedient Approach for the Synthesis of 1-Alkyl-4-propionylpyrrolidin-2-ones

Abstract

A simple and useful tandem addition–cyclization reaction of primary amines on a prepared α-functionalized propylvinyl ketone 3 in methanol at reflux is a promising route for the synthesis of a new family of 1-alkyl-4-propionylpyrrolidin-2-ones 4.

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GRAPHICAL ABSTRACT

Keywords:

• Primary amines
• 4-propionylpyrrolidin-2-ones
• propylvinyl ketone

ACKNOWLEDGMENTS

The authors thank the Tunisian Ministry of Higher Education and Scientific Research for financial support and Professor Jacques Lebreton (University of Nantes, France) for logistical help.

Notes

^a Yields refer to the pure isolated products after chromatography.