Design, Synthesis, and Antibacterial Evaluation of Some Novel 3′-(Phenylamino)-1′H-spiro[indoline-3,2′-quinazoline]-2,4′(3′H)-dione Derivatives

Abstract

A combinatorial synthesis and evaluation of antibacterial activity against clinically isolated resistant strains of Gram-positive and Gram-negative bacteria of 3′-(phenylamino)-1′H-spiro[indoline-3,2′-quinazoline]-2,4′(3′H)-dione derivatives is described.

GRAPHICAL ABSTRACT

Keywords:

• Alum
• antibacterial activity
• isatoic anhydride
• spirooxindole
• quinazoline

ACKNOWLEDGMENT

We gratefully acknowledge financial support from the Research Council of Iran National Science Foundation (INSF).

Notes

^a Isolated yields.

^a Inhibition zone (mm).

^b Minimum inhibitory concentration (µg/ml).

^c Not tested.