Abstract
The relative merits of two different Baylis–Hillman approaches toward the preparation of coumarin derivatives, containing peptide-like side chains, have been explored. In one approach, use of methyl acrylate as the activated alkene requires a protecting group strategy, an approach that is not necessary when using tert-butyl acrylate.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors thank the National Research Foundation (NRF Grant No. 62273), the Medical Research Council of South Africa (MRC), and Rhodes University for financial support. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and therefore the NRF does not accept any liability in regard thereto.