Efficient Room-Temperature Synthesis and Antimicrobial Study of Novel 2-Aroylbenzofuran-3-ols from Substituted Methyl Salicylates and Phenacyl Bromides

Abstract

The article describes a convenient and efficient synthetic route for the construction of 2-aroylbenzofuran-3-ols from readily available diverse methyl salicylates and phenacyl bromides using K₂CO₃ as catalyst in dimethylformamide as solvent at room temperature. The reaction involves two steps, which occur in quick succession within 1 h to deliver the product with reasonably high yields. All the synthesized 2-aroylbenzofuran-3-ols (4a–u) were subjected for their antimicrobial studies, and some of these have shown prominent activity.

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GRAPHICAL ABSTRACT

Keywords:

• 2-Aroylbenzofuran-3-ols
• Antimicrobial activity
• K₂CO₃/DMF
• methyl salicylate
• phenacyl bromide
• room temperature

ACKNOWLEDGMENT

The authors are thankful to the authorities of Jain University for financial support and encouragement.

Notes

Notes. ++++ = 15 mm, +++ = 11 mm, ++ = 8 mm, and + = 4 mm.

Notes. Each reaction took less than 1 h. Extra stirring time (15 min) was allowed to ensure that no traces of starting compounds were left.