Abstract
The article describes a convenient and efficient synthetic route for the construction of 2-aroylbenzofuran-3-ols from readily available diverse methyl salicylates and phenacyl bromides using K2CO3 as catalyst in dimethylformamide as solvent at room temperature. The reaction involves two steps, which occur in quick succession within 1 h to deliver the product with reasonably high yields. All the synthesized 2-aroylbenzofuran-3-ols (4a–u) were subjected for their antimicrobial studies, and some of these have shown prominent activity.
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GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
The authors are thankful to the authorities of Jain University for financial support and encouragement.
Notes
Notes. ++++ = 15 mm, +++ = 11 mm, ++ = 8 mm, and + = 4 mm.
Notes. Each reaction took less than 1 h. Extra stirring time (15 min) was allowed to ensure that no traces of starting compounds were left.