DPT-Mediated Synthesis of 2-Aminoimidazolidin-4-ones from Thioureas Tethered to Amides

Abstract

2-Aminoimidazolidin-4-ones have been synthesized by using di-2-pyridyl thiocarbonate (DPT), taking the thioureas tethered to amides as the starting materials. Both the primary amides and secondary amides have been subjected to this cyclization method and in general this simple and convenient method was found to ensure good to excellent yields (81–99%).

GRAPHICAL ABSTRACT

Keywords:

• Aminohydantoin
• aminoimidazolidinone
• cyclization
• synthesis

Notes

^a Compounds are known, and the spectral data are available in Refs. 10 and 11.

^b Isolated yields.

^c THF was used as solvent.

^d CH₃CN was used as solvent.

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.