Abstract
The synthesis of coumarins by hydroxyalkylation of phenols with ethyl acetoacetate (via Pechmann reaction) is attempted using magnetically separable and reusable CuFe2O4 nanoparticles in water.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications ® for the following free supplemental resource(s): Full experimental and spectral details.]
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENT
This research is supported by the Islamic Azad University, Ayatollah Amoli Branch.
Notes
a Reaction conditions: resorcinol (1 mmol) and ethyl acetoacetate (1.2 mmol).
b Isolated yield.
a Isolated yields of pure products.
a Reaction condition: resorcinol (1 mmol), ethyl acetoacetate (1.2 mmol), CuFe2O4 nanoparticles as a catalyst 5 mol% in water.
b Isolated yield.