Solvent-Free Synthesis of Dihydropyridines and Acridinediones via a Salicylic Acid–Catalyzed Hantzsch Multicomponent Reaction

Abstract

A multicomponent Hantzsch synthesis of 1,4-dihydropyridines and acridinediones from commercially available aldehydes, ammonium acetate, and ethyl acetoacetate or dimedone, in the presence of salicylic acid as an efficient catalyst, in good yield and short reaction time is reported.

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GRAPHICAL ABSTRACT

Keywords:

• Acridinediones
• 1,4-dihydropyridines
• Hantzsch
• multicomponent
• salicylic acid

Notes

^a All reactions were performed using benzaldehyde (1 equiv.), ethyl acetoacetate (2 equiv.), and ammonium acetate (4 equiv.).

^b Isolated yields.

^a All reactions were performed using aldehyde (1 equiv.), ethyl acetoacetate (2 equiv.), ammonium acetate (4 equiv.), and salicylic acid (0.2 equiv.) at 80 °C.

^b Isolated yields.

^a All reactions were performed using aldehyde (1 equiv.), dimedone (2 equiv.), ammonium acetate (4 equiv.), and salicylic acid (0.2 equiv.) at 80 °C.

^b Isolated yields.