Synthesis of Entacapone by Pd-Catalyzed Heck Coupling Reaction

Abstract

Synthesis of entacapone from 4-iodo-2-methoxy-phenol with 2-cyano-N,N-diethylacrylamide by palladium-catalyzed Heck reaction, as a key step, is described.

GRAPHICAL ABSTRACT

Keywords:

• 2-Cyano-N,N-diethyl-acrylamide
• 4-iodo-2-methoxy-phenol
• Heck reaction and entacapone

ACKNOWLEDGMENTS

The authors are grateful to Suven Life Sciences management for allowing them to publish these results and Dr. Vasanth Kumar for the preliminary laboratory work.