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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 9
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Original Articles

One-Pot Synthesis of Mannich Bases Under Solvent-Free Conditions

Onur Demirkol Department of Chemistry, Art and Science Faculty, Çukurova University, Adana, Turkey
,
Dilek Akbaşlar Department of Chemistry, Art and Science Faculty, Çukurova University, Adana, Turkey
,
Sultan Giray Department of Chemistry, Art and Science Faculty, Çukurova University, Adana, TurkeyCorrespondence[email protected]
&
B. Barış Anıl Department of Chemistry, Science Faculty, Ataturk University, Erzurum, Turkey
Pages 1279-1285 | Received 18 Mar 2013, Published online: 28 Mar 2014
 
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Abstract

A mild and practically convenient one-pot procedure for the Mannich reaction via condensation of amines, aldehydes and malonates, β-ketoesters, or β-dicarbonyl compounds has been carried out without using any organic solvent, metallic catalyst, or Lewis acids or bases at room temperature. The present protocol offers several advantages, such as goods yields, simple procedure with easy workup, and the absence of any volatile, hazardous organic solvents and metallic catalyst.

GRAPHICAL ABSTRACT

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.

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