Highly Efficient Synthesis of Trioxopyrimidine-Based Chalconoids Under Solvent-Free Conditions

Abstract

Straightforward procedures for the fast and efficient synthesis of differently substituted barbituric acid–based chalconoids under solvent-free conditions were developed.

GRAPHICAL ABSTRACT

Keywords:

• Barbituric acid
• chalconoids
• screening
• solvent-free reaction

Notes

^a Ratio of aldehyde/barbituric acid.

^b The reaction time was measured as the time from addition of piperidine to the time of removal of the reaction vessel from the oil bath.