Ammonium Iodide–Promoted Cyclization of Aryl-Substituted Carboxylic Acids

Abstract

An efficient procedure was developed for direct preparation of aryl-substituted lactones from corresponding aryl carboxylic acids, which was promoted by ammonium iodide. In this protocol, aryl carboxylic acids were treated with ammonium iodide, potassium bromide, and oxidant Oxone in a mixture of acetonitrile and 2,2,2-trifluoroethanol (6:4) at room temperature for 12 h, resulting in corresponding aryl lactones in moderate to good yields.

GRAPHICAL ABSTRACT

Keywords:

• Ammonium iodide
• benzylic cyclization
• lactone

Notes

^a Yield of isolated 2a.

^a Yield of isolated 2.