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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 11
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Original Articles

Synthesis of New Tandospirone Analogues Carrying 1-(3-(Trifluoromethyl)phenyl)piperazine

Omer Tahir Gunkara Faculty of Science and Arts, Yildiz Technical University, Istanbul, Turkey
,
Bilgesu Onur Sucu Faculty of Science and Arts, Yildiz Technical University, Istanbul, Turkey
,
Muge Guleli Faculty of Science and Arts, Yildiz Technical University, Istanbul, Turkey
&
Nuket Ocal Faculty of Science and Arts, Yildiz Technical University, Istanbul, TurkeyCorrespondence[email protected]
Pages 1619-1628 | Received 11 Oct 2013, Published online: 14 May 2014
 
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Abstract

New tandospirone analogues containing a 1-[3-(trifluoromethyl)phenyl]piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)2. The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported.

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