Efficient Microwave-Assisted Esterification Reaction Employing Methanesulfonic Acid Supported on Alumina as Catalyst

Abstract

A rapid and efficient protocol assisted by microwave irradiation for the synthesis of esters using methanesulfonic acid (CH₃SO₃H) supported on Al₂O₃ (AMA) as catalyst and free of solvent is described. The products were obtained in good yields and purity, with reduced reaction time, and the process is simple and environmentally benign.

GRAPHICAL ABSTRACT

Keywords:

• AMA catalyst
• microwave irradiation
• solvent-free
• synthesis of esters

ACKNOWLEDGMENT

We thank SANICO S.A.I.&C. (Argentina) because it allocated the Anton Parr Monowave 300 reactor to check the first reactions developed in this study.

Notes

Note. Yields correspond to isolated yield. All compounds were fully characterized by ¹H and ¹³CNMR spectra.

^a NMR spectra are in accordance with those reported in NMR Catalogues: Poucher and Campbell, Aldrich Library of NMR Spectra Aldrich NMR Library, and Aldrich Spectral Viewer v 1.1.10.

^b NMR spectra are in accordance with those reported in the Spectral Database for Organic Compounds, SDBS, by National Institute of Advanced Industrial Science and Technology (AIST), Japan.

^c WSS, spectral data were obtained from Wiley Subscription Services, Inc. (US).

^d Diester derivatives.

Note. All compounds were fully characterized by ¹H and ¹³CNMR spectra.

^a Diester derivatives.