Abstract
A simple, efficient, and ecofriendly one-pot method has been reported for the synthesis of polyhydroquinolines in excellent yield using nucleophilic heterocyclic carbene as catalyst. The generalized approach is the Hantzsch four-component reaction of aromatic aldehyde, ethyl acetoacetate, cyclic 1,3-diketone, and ammonium acetate.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
We sincerely thank SAIF, Punjab University, Chandigarh, for providing microanalyses and spectra.
Notes
a Benzaldehyde (1 mmol), ethylacetoacetate (1 mmol), dimedone (1 mmol), and ammonium acetate (1 mmol) + 60 °C.
b See Ref. 37.
a Araldehydes + ethylacetoacetate + dimedone + ammonium acetate + NHC (5 mol%).