Ultrasound-Promoted Rapid and Efficient Iodination of Aromatic and Heteroaromatic Compounds in the Presence of Iodine and Hydrogen Peroxide in Water

Abstract

A rapid and efficient ultrasound-promoted protocol for iodination of aromatic and heteroaromatic compounds, using molecular iodine in the presence of aqueous hydrogen peroxide in water without any cosolvent, has produced versatile iodinated organic molecules with potential application in organic synthesis and medicine in short reaction times and good to excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• Iodinated organic compounds
• iodination reaction
• mild reaction conditions
• reaction in water
• ultrasound

Notes

^a Reaction conditions: 2 mmol of compound 1, the indicated amount of I₂, the indicated amount of H₂O₂ (30%), and 10 mL of H₂O were maintained under sonication (20 KHz, 100 W) for the period of time presented.

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