Abstract
Silica-supported perchloric acid (HClO4-SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
We sincerely thank Sri G. Ganga Raju, chairman, and G. Rama Raju, director, Laila Impex, for analytical support.
Notes
a Isolated yield.
a Isolated yield.