Synthetic Strategies for Fused Benzothiazoles: Past, Present, and Future

Abstract

Benzothiazole is used as a building block in organic synthesis, which serves as a key template for the development of various therapeutic agents and shows a wide spectrum of activities. The attractive application of benzothiazole in organic synthesis is undoubtedly due to the highly reactive C-2 amino group, which is responsible for the change in its bioactivity. The construction of a poly-heterocyclic compound with the fused hetero-systems has attracted increasing attention because of the diverse range of potential therapeutic activities. Significant efforts have been undertaken to exploit different synthetic routes to these compounds. This article gives a comprehensive account of the synthetic utility of benzothiazole employed in the design and synthesis of different types of compounds containing fused heterocyclic rings with greater emphasis on recent literature.

GRAPHICAL ABSTRACT

Keywords:

• 2-Amino benzothiazole
• benzothiazole
• fused heterocyclic compound
• multicomponent reactions (MCR)
• thiazole derivative

View correction statement:

Corrigenda

ACKNOWLEDGMENTS

The authors are thankful to the Department of Chemistry, Gujarat University, Ahmedabad, Gujarat, India, for providing the necessary facilities and the UGC–Infonet and INFLIBNET Gujarat University for providing e-source facilities.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.