Abstract
An alternative and efficient telescopic approach to the synthesis of 3-(4-chloro butyl)-1H-indole -5-carbonitrile (2), a key intermediate in the synthesis of vilazodone hydrochloride (1), is described.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors thank the management of Dr. Reddy's Laboratories Limited for allowing us to carry out the present work. The authors are also thankful to their colleagues in the Analytical Research Department for their cooperation.
Notes
Communication No. IPDO IPM-00357.