Alternative Approach to Synthesis of 3-(4-chloro butyl)-1H-indole-5-carbonitrile: A Key Intermediate of Vilazodone Hydrochloride, an Antidepressant Drug

Abstract

An alternative and efficient telescopic approach to the synthesis of 3-(4-chloro butyl)-1H-indole -5-carbonitrile (2), a key intermediate in the synthesis of vilazodone hydrochloride (1), is described.

GRAPHICAL ABSTRACT

Keywords:

• Fisher indole synthesis
• indoles
• vilazodone hydrochloride

ACKNOWLEDGMENTS

The authors thank the management of Dr. Reddy's Laboratories Limited for allowing us to carry out the present work. The authors are also thankful to their colleagues in the Analytical Research Department for their cooperation.

Notes

Communication No. IPDO IPM-00357.