Basic Ionic Liquid [bmIm]OH–Mediated Gewald Reaction as Green Protocol for the Synthesis of 2-Aminothiophenes

Abstract

A simple, efficient, and environmental friendly procedure was developed based on the Gewald reaction for the synthesis of 2-aminothiophenes using a basic ionic liquid [bmIm]OH as both catalyst and solvent. Besides being a green protocol, the method offers advantages of successful synthesis of a variety of alkyl, aryl, alkoxy, and alkylamino-2-aminothiophenes in good yields.

GRAPHICAL ABSTRACT

Keywords:

• 4-Alkoxythiophenes
• 2-aminothiophenes
• basic ionic liquid
• [bmIm]OH
• Gewald reaction
• ionic liquid

ACKNOWLEDGMENTS

Part of this work has been submitted as a Ph.D. thesis to Panjab University (PU). The authors thank the chairman, UIPS, PU, Chandigarh, for providing the facilities.

Notes

^a Second recycling of IL.

^b Third recycling of IL.

Note. Ref., reference.

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