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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 1
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Original Articles

Synthesis of 14,15-EET from Arachidonic Acid Using Urea–Hydrogen Peroxide as the Oxidant

Fuchun Xie Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA
,
Bingbing X. Li Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA
,
Nabil J. Alkayed Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA
&
Xiangshu Xiao Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USACorrespondence[email protected]
Pages 105-110 | Received 09 Jul 2014, Published online: 20 Oct 2014
 
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Abstract

14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea–hydrogen peroxide (UHP) as the oxidant.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

We are grateful for Dr. Sanjiv Kaul for discussions and the Knight Cardiovascular Institute.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.

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