Abstract
An atom-economical and environmentally friendly method for synthesis of bromo-substituted alkynyl sulfides has been developed. In the absence of any additive, alkynyl bromides could react with tetrahydrothiophene to give bromo-substituted alkynyl sulfides in moderate to perfect yields.
GRAPHICAL ABSTRACT
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Notes
a Reaction conditions: 1a (0.30 mmol), base (3.0 equiv), solvent (2 mL), 24 h, 120 °C.
b Isolated yield.
c THT (5 equiv.).
d 80 °C.
e 140 °C.
a Reaction conditions: 1a (0.3 mmol), THT (4 ml), 120 °C.
b Isolated yield.