PMA-SiO₂–Mediated MCR in PEG-400: A Greener aza-Friedel–Crafts Reaction Leading to 3-Arylmethyl/Diarylmethyl Indoles

Abstract

A greener approach for the synthesis of 3-arylmethyl/diarylmethyl indoles has been achieved via a PMA-SiO₂-mediated three-component reaction (the aza-Friedel–Crafts reaction) involving indoles, aldehydes, and N,N-disubstituted anilines in PEG-400. A variety of indole derivatives were prepared by using this operationally simple and straightforward methodology in acceptable yields.

GRAPHICAL ABSTRACT

Keywords:

• Aldehyde
• aniline
• indole
• MCR
• PEG-400
• PMA-SiO₂

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Corrigenda

ACKNOWLEDGMENTS

D. N. K. Reddy thanks A. Sanjay Reddy, Upadhya Thimanna, Vilas Dhanukar, and the management of CPS, DRL, Hyderabad, India, for support and encouragement.

SUPPORTING INFORMATION

Full experimental detail and spectral data for this article can be accessed on the publisher’s website.