Synthesis, Structural Stability Calculation, and Antibacterial Evaluation of Novel 3,5-Diphenylcyclohex-2-en-1-one Derivatives

Abstract

Starting with 3,5-diphenylcyclohex-2-en-1-one, 3,5-diphenylcyclohex-2-en-1-semicarbazone, 1-chloro-3,5-diphenylcyclohex-2-en-2-carbaldehyde, and 3,5-diphenylcyclohex-2-en-1-hydrazone were synthesized via the reactions with semicarbazide hydrochloride, POCl₃/ dimethylformamide, and hydrazine hydrate, respectively. These products were used as key intermediates for the preparation of novel series of tetrahydrobenzothiadiazol-1-oxide, indazole, benzo-thiazepines, pentahydroxyhexylidene and N-thiazines. Some of these derivatives exhibit high antibacterial activity against Gram-positive bacteria.

GRAPHICAL ABSTRACT

Keywords:

• Antibacterial
• diphenylcyclohexenone
• indazole
• pentahydroxyhexylidene
• tetrahydrobenzothiazepine
• thiazolidinone

SUPPLEMENTAL MATERIAL

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