Design, Synthesis, and Antimicrobial Evaluation of Novel Thienopyrimidines and Triazolothienopyrimidines

Abstract

2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyrimidines. The proclivity of these compounds toward one-carbon donor reagents such as carbon disulfide, phenyl isothiocyanate, and aromatic aldehydes was investigated. The structures of all synthesized compounds were ascertained by spectral and analytical data. The antimicrobial activity of the target synthesized compounds was tested against various microorganisms.

GRAPHICAL ABSTRACT

Keywords:

• Antimicrobial activity
• 2-cyanoacetohydrazide
• thienopyrimidines
• triazolothienopyrimidines

SUPPORTING INFORMATION

Full experimental details and spectroscopic data for compounds 4–21 can be accessed on the publisher’s website.