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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 12
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Original Articles

Practical Approach for Synthesis of 2-Amino-benzoxazole in Water

, &
Pages 1471-1475 | Received 09 Dec 2014, Published online: 05 May 2015
 

Abstract

A practical copper-catalyzed amination of benzoxazole with secondary amine in water has been developed. This reaction has proved to be effective to some cyclic amines, and the substituted group of nitrogen has a great impact on the amination reaction. A copper-catalyzed/ amine-induced ring opening of the benzoxazole and recyclization/oxidation mechanism was also proposed.

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