Abstract
A practical copper-catalyzed amination of benzoxazole with secondary amine in water has been developed. This reaction has proved to be effective to some cyclic amines, and the substituted group of nitrogen has a great impact on the amination reaction. A copper-catalyzed/ amine-induced ring opening of the benzoxazole and recyclization/oxidation mechanism was also proposed.
GRAPHICAL ABSTRACT
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SUPPORTING INFORMATION
Full experimental details, 1H and 13C NMR spectra, and MS data for this article can be accessed on the publisher's website.