Investigations of the Chemistry of Alkyl Phosphites Toward Nitrogen-Containing Compounds: Efficient Approaches to α-Amino-, β-Amino-, and/or Enaminophosphonates

Abstract

In this study, we report recent investigations of the chemical reactivity of alkyl phosphites, mainly trialkyl and dialkyl phosphites, with molecules containing different nitrogen-containing compounds reported by us and other research groups over the past 25 years. Previous ground-breaking important reports are also considered. The reviewed investigations in this article are grouped according to only the type of the nitrogen-functional groups [amines (primary, secondary, and tertiary amines), imines, amides, thioamides, nitriles, isocyanates, isothiocyanates, oximes, hydrazones, diazo, and azides] and not according to the site of attack or the final products. Furthermore, the present review article focuses on the synthesis of α-amino-, β-amino-, and/or enaminophosphonates. These compounds have important roles in pharmaceutical chemistry.

GRAPHICAL ABSTRACT

Keywords:

• Aminophosphonates
• dialkyl hydrogenphosphonates
• enaminophosphonates
• nitrogen-containing compounds
• trialkyl phosphites