Facile Denitrosation of Cyclic N-Nitrosamines with Hydrazoic Acid

Abstract

A simple and facile method for the denitrosation of cyclic N-nitrosamines using HN₃ (concentrated H₂SO₄ + NaN₃) is reported. In this method, limited usage of this reagent does not affect the carbonyl group.

GRAPHICAL ABSTRACT

Keywords:

• Denitrosation
• 1,4-diazepan-5-one
• hydrazoic acid
• piperidin-4-one
• Schmidt rearrangement

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