Straightforward Approach Toward Dihydrothiazoles via Intramolecular Bromocyclization

Abstract

An intramolecular bromonium ion–assisted cyclization with sulfur as an internal nucleophile is described. Starting from benzoyl chlorides, this method provides an easy procedure for the synthesis of dihydrothiazole derivatives in moderate to good yields.

GRAPHICAL ABSTRACT

Keywords:

• Benzoyl chloride
• bromocyclization
• dihydrothiazole
• N-bromosuccinimide (NBS)

SUPPLEMENTAL MATERIAL

Full experimental details and ¹H and ¹³C NMR spectra for this article can be accessed on the publisher’s website.