Facile one-pot synthesis of 2-arylbenzothiazoles catalyzed by H₃PO₄/TiO₂-ZrO₂ (1/1) under solvent-free conditions

ABSTRACT

A highly efficient and simple protocol for the preparation of 2-arylbenzothiazoles through condensation of 2-aminothiophenol and different aldehydes in the presence of H₃PO₄/TiO₂-ZrO₂(1/1)-cetyl pyridinium bromide (CPB) is described. The reaction proceeded under mild and solvent-free conditions to afford 2-arylbenzothiazole derivatives. In this method, the title compounds were obtained in good to excellent yields and short reaction times. The structures of synthesized products were identified by infrared, ¹H NMR, ¹³C NMR, and mass spectroscopy.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aldehyde
• 2-aminothiophenol
• 2-arylbenzothiazole
• H₃PO₄/TiO₂-ZrO₂
• synthesis