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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 8
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Original Articles

Efficient ecofriendly synthesis of pyrazole acryloyl analogs by amino acid catalysis

Faryal ChaudhryInstitute of Chemistry, University of the Punjab, Lahore, Pakistan;Department of Chemistry, Kinnaird College for Women, Lahore, Pakistan
,
Nadia AsifInstitute of Chemistry, University of the Punjab, Lahore, Pakistan
,
Syed Salman ShafqatDepartment of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, Sarawak, Malaysia
,
Amir Azam KhanDepartment of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, Sarawak, Malaysia
,
Munawar Ali MunawarInstitute of Chemistry, University of the Punjab, Lahore, PakistanCorrespondence[email protected]
&
Misbahul Ain KhanInstitute of Chemistry, University of the Punjab, Lahore, Pakistan;Department of Chemistry, Islamia University of Bahawalpur, Bahawalpur, Pakistan
Pages 701-709 | Received 05 Jan 2016, Published online: 28 Apr 2016
 
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ABSTRACT

An easy and effective green approach of Knoevenagel condensation and arylidene formation with the substrates involves pyrazole-3-carbaldehydes and active methylenes under catalytic action of glycine (the simplest amino acid) in dimethylsulfoxide. These reactions were successfully carried out at room temperature.

GRAPHICAL ABSTRACT

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