One-pot synthesis of chromeno[2,3-b]isoindolo[1,2-e]pyrrole-12,13-dione derivatives by sequential reaction of ninhydrin, 2-aminochromen-4-ones and arylamines

ABSTRACT

Stirring an equimolar mixture of ninhydrin 1 and 2-aminochromen-4-ones 2 in CH₃COOH at room temperature produced 6a,11a-dihydroxy-6H-chromeno[2,3-b]indeno[2,1-d]pyrrole-11,12(6aH,11aH)-diones 3, which on heating with aromatic amines 6 in acetic acid produced 11b-hydroxy-7-N-arylimino-6H-chromeno[2,3-b]isoindolo[1,2-e]pyrrole-12,13(11bH)-diones 7.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2-Aminochromen-4-one
• 1-benzopyran
• indenopyrrole
• isoindolopyrrole
• ninhydrin

Acknowledgments

We gratefully acknowledge the Department of Science and Technology–Funding for Infrastructure in Science and Technology for instrumental help at RKMVC College; University of Kalyani and IICB, Jadavpur for spectral analysis; and finally the college authority for providing other research facilities.