Cu(OTf)₂-catalyzed synthesis of highly substituted 1-methoxy imidazoles via (3 + 2) cycloaddition between imino carbenoids and nitriles

ABSTRACT

A Cu(OTf)₂-catalyzed simple synthetic approach for highly substituted 1-alkoxy imidazole has been described. This protocol involves (3 + 2) cycloaddition of oximino carbenoids with organo nitriles. This method has wide substrate scope and tolerates alkyl, aryl, substituted aryl, vinyl, and ester nitriles.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1-Alkoxy imidazoles
• (3 + 2) cycloaddition reaction
• α-diazo carbonyl compounds
• imino carbenoids
• organo nitriles

Acknowledgment

The authors thank the administration and the management of Karunya University for their constant support and encouragement.