ABSTRACT
An efficient and green approach has been developed for the synthesis of polyhydroquinoline derivatives via Hantzsch condensation reaction directly from corresponding substituted aromatic and aliphatic aldehydes, β-keto compounds, active methylene compounds, and ammonium chloride using recyclable polymer-supported sulfonic acid catalyst under aqueous conditions. Environmental acceptability, operational simplicity, low cost, excellent functional group compatibility, and high yields are the important features of this protocol.
GRAPHICAL ABSTRACT
![](/cms/asset/66910eab-9573-4d1e-bd47-63f1c5aa3d03/lsyc_a_1213850_uf0001_oc.jpg)
Acknowledgments
The authors thank Vilas Dahanukar, Upadhya Timmana, H. Rama Mohan, and the analytical group of CPS-DRL for spectral data. A. V. D. Rao thanks the CPS-DRL (DRL Communication no: IPDO IPM-00510), Hyderabad, India, for encouragement.