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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 20
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Original Articles

Polyethylene glycol in water: Simple, efficient, and catalyst-free synthesis of 4H-pyran derivatives

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Pages 1665-1670 | Received 24 Mar 2016, Published online: 17 Aug 2016
 

ABSTRACT

A green, one-pot, multicomponent method for the synthesis of diverse library of 4H-pyran derivatives such as 4-phenyl-4H-pyrans, spirochromenes, and dihydropyrano[3,2-c]chromines was developed using polyethylene glycol (PEG-600) as promoting reaction medium in water. The 4-phenyl-4H-pyran dihydropyrano[3,2-c]chromine derivatives were synthesized by a three-component reaction of aromatic aldehyde, malononitrile, and cyclic 1,3-dione/4-hydroxy coumarin at room temperature and reflux respectively. The promising points for the present methodology are efficiency, generality, high yield, short reaction time, cleaner reaction profile, ease of product isolation, potential to recycle reaction medium, and agreement with green chemistry protocols, making it a useful and attractive process for the synthesis of 4H-pyran derivatives.

GRAPHICAL ABSTRACT

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