One-pot synthesis of oxoisoindoline-1,2,3-triazole hybrid by a Ugi–click reaction

ABSTRACT

1,2,3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl isocyanide in ethanol. The resultant Ugi adduct underwent a copper-catalyzed click reaction, producing the desired products in good yields.

GRAPHICAL ABSTRACT

KEYWORDS:

• Click reaction
• multicomponent reaction
• one-pot synthesis
• 1,2,3-triazole
• Ugi reaction