Efficient catalyst-free synthesis of diversified bis (spirooxindoles) via one-pot, three-component reaction

ABSTRACT

A catalyst-free, one-pot synthesis of bis-spirooxindoles has been carried out by a three-component reaction of bis-isatins, malononitrile, and various cyclic enolizable carbonyl compounds in ethylene glycol at 100 °C. The protocol provides an easy and simple route for the synthesis of such complex compounds, in short reaction times and high yields. No chromatographic techniques have been employed for the purification of the compounds.

GRAPHICAL ABSTRACT

KEYWORDS:

• Bis(spirooxindoles)
• ethylene glycol
• isatin
• MCRs

Acknowledgment

The authors acknowledge DU-DST for providing HRMS-LC analysis.