Amino acid catalyzed reactions. A facile route to some heteroarylbispyrazoles

ABSTRACT

This newly designed route assembled a pyrazole ring with an aldehydic functionality over another pyrazole moiety. Further, formyl group was exploited in different routes such as condensation reactions, imidazole and pyrimidone/thione synthesis. The present reactions were performed with glycine, a facile catalyst, and the results were compared well with those of conventional methods.

GRAPHICAL ABSTRACT

KEYWORDS:

• Arylidenes
• biginelli reaction
• bispyrazoles
• imidazoles
• Knoevenagel condensation

Acknowledgment

We thank Higher Education Commission (HEC), Pakistan, for the award of Indigenous and IRSIP fellowships (to Faryal Chaudhry, Sadia Naureen and Fatima Ijaz).