ABSTRACT
Highly regioselective ring cleavage of chalcone epoxides to bromohydrins has been carried out in good yields with LiBr in the presence of β-CD using DMSO-H2O as solvent system. The ring-opened product, i.e., bromohydrin, was well adapted to IBX-mediated oxidation in such a fashion that the bromohydrins are transformed to their corresponding 1,2,3-triketones in moderate-to-good yields in one pot.
GRAPHICAL ABSTRACT
Acknowledgments
The authors wish to express their gratitude to DST, New Delhi, for providing HRMS and NMR facility and CSIR, New Delhi, for awarding SRF to S. Kumar and N. Verma.